Polynucleotides
Plinest and Newest are polynucleotide bio-stimulating gels extracted from salmon trout DNA fragments. They can be used under the eyes, on the face, neck, decolletage, scalp, inner arms, and thighs. Polynucleotides work like fuel to galvanise your cells in all facial layers to work at their maximum capacity. Therefore, they are considered a natural bio-regenerative treatment as, unlike Botox and fillers, your skin cells are responsible for generating the myriad of benefits from this treatment.
Polynucleotides work by stimulating fibroblasts which encourages cell turnover, improves elasticity, boosts collagen production and hydrates skin thanks to powerful wound-healing polymers. They also calm inflammation and rebalance the activity of pigment-producing cells to create an even and refreshed skin tone.
Polynucleotides are an excellent treatment option for those with fine lines and wrinkles, acne scarring, dark under-eye circles, and skin with poor texture, tone, and laxity. When used on the scalp, polynucleotides are also an incredibly effective treatment for those suffering from hair loss.
Polynucleotides immediately hydrate and tighten the skin. However, the visible impact of their biostimulatory action occurs 1-2 months post-procedure and lasts for 6-9 months after treatment. 3-4 sessions are advised 2-4 weeks apart, with a maintenance treatment recommended every 6-9 months.
Polynucleotides cost £250 per session for the initial course, with a single maintenance treatment costing £275 afterward. The treatment lasts 30-45 minutes, depending on the treatment area. Downtime is 24 hours.
FAQs
Polynucleotides are injected into the face using a needle or cannula and work in multiple different ways to:
- Draw in water to hydrate and plump the skin.
- Work as an antioxidant to neutralise free radicals and protect against cellular damage, leading to skin thinning and ageing.
- Stimulate collagen production to thicken and strengthen the dermis to improve the appearance of fine lines and wrinkles.
- Promote the differentiation of fibroblasts into myofibroblasts to contour and tighten the skin.
- Attract stem cells to repair tissue damage.
- Block the activity of osteoclasts, which break down bone, to better preserve the facial skeleton for improved structural support to prevent sagging.
- Reduce pigmentation by spreading pigment-producing cells in the skin and stop them from over-producing melanin.
Polynucleotides are injected under the eyes and eyebrows and work in numerous ways:
Lighten dark under-eye circles.
As we age, our delicate under-eye skin gets thinner and more translucent. This reveals the underlying muscle, which gives the region a purple-blue hue. The vascular network under the eye also shrinks, leading to the deposition of a dark pigment called haemosiderin. Polynucleotides both thicken the skin to conceal the muscle and promote the development of new blood vessels to wash away the haemosiderin.
Reduce puffy under eyes.
Polynucleotides enhance the vascular network in the under-eye area to drain away excess fluid which causes puffy under eyes.
Lift mild hooded eyelids.
When administered below the brow, polynucleotides cause cells to differentiate into myofibroblasts, tightening the skin and subtly lifting the eyelid to help with hooded brows.
Fill under eye hollows.
As we age, our eye socket recedes, we lose fat, and our skin thins resulting in under eye hollowing. Polynucleotides work by blocking the activity of cells which breakdown bone. They also thicken the skin by generating new collagen, protecting cells from free radical damage, and attracting water to plump up the under-eye area.
Improve the appearance of eye bags.
The muscle that encircles our eye and the ligament that tethers it to the eye socket become weaker with age. This allows the orbital fat behind the muscle to bulge, causing eye bags. Polynucleotides promote a more even spread of the fat, resulting in an improved eyelid-cheek contour.
Minimise the appearance of crow’s feet.
Polynucleotides stimulate collagen production to thicken and strengthen the dermis to plump out fine lines and wrinkles.
Polynucleotides work by stimulating and maintaining hair in its growing state, known as the anagen phase, and prevent it from entering its shedding state, known as the catagen phase. This thickens and improves hair density on the scalp and protects against further hair loss.
Polynucleotides achieve this by:
- Activating growth factor pathways to stimulate the proliferation of hair follicles.
- Supporting cellular repair and regeneration to aid in the recovery of damaged hair follicles.
- Dampening pro-inflammatory pathways to help reduce inflammation in the scalp to create a more favourable environment for hair growth.
- Protecting the skin cells on the scalp from damage by free radicals.
- Improving microcirculation to enhance blood flow to deliver essential nutrients and oxygen to hair follicles.
- Stimulating collagen production to strengthen the connective tissue around hair follicles.
The ideal age to start polynucleotides varies depending on individual skin concerns and goals. Generally, individuals in their mid-20s to early 30s can benefit from polynucleotides as a preventative measure to maintain healthy skin and boost collagen production. For those in their mid-30s and beyond, polynucleotides effectively address early signs of ageing, such as fine lines, wrinkles, and sun damage. Polynucleotides are also suitable at any age for treating specific issues like acne scars or hyperpigmentation.
Polynucleotides should be considered for hair loss when hair starts to thin or there is mild to moderate hair loss. This includes recession at the temples, causing an 'M'-shaped hairline, and loss of hair at the crown of the head. The treatment is not suitable for areas of baldness where the skin has become shiny, as the follicles are closed and cannot be stimulated with polynucleotides.
Polynucleotides are an excellent treatment option for most people. However, they are not suitable for those:
- Who are pregnant or breastfeeding.
- Have a fish allergy.
- Are immunodeficient.
- Have an active skin infection in the targeted treatment area.
- Reschedule if you are unwell.
- Please arrive make-up-free with a cleansed face to help avoid infection.
Before the treatment, you will be guaranteed a full consultation so we can listen to your concerns and goals, take a comprehensive medical history, assess your face, establish whether polynucleotides are the right treatment option for you, and develop a bespoke treatment plan together. We will discuss the risks and benefits of the procedure, and if you aren't sure, we will insist you go away and take some time to decide if you want to proceed with the treatment.
Polynucleotides can be administered using either a cannula or a needle.
A cannula is a blunt tube inserted under the skin through a small hole created by a small needle.
Numbing cream is applied to the needle's insertion site so you will not feel anything. As the cannula moves under the skin, you may feel some mild tugging, which some find uncomfortable rather than painful.
If using a needle, many small injections of polynucleotides will distribute the product over the face. A numbing cream will be applied, but a stronger product can sometimes sting.
A small puncture hole may be visible for 24 hours if a cannula is used.
Many small, raised bumps will be visible for 24 hours if a needle is used.
We will advise the following after your treatment:
- Do not touch or rub the treated area until the following day.
- Do not apply makeup for 12 hours.
- Avoid vigorous exercise and alcohol for 48 hours.